Anidulafungin dosing during CRRT: do not underestimate adsorption!
نویسندگان
چکیده
منابع مشابه
Anidulafungin dosing during CRRT: do not underestimate adsorption!
Two recent papers in Critical Care discuss the use of echinocandins in general [1], and anidulafungin in particular [2], during continuous renal replacement therapy (CRRT). Being highly protein bound and predominantly nonrenally eliminated drugs, echinocandins are barely removed by convection and thus require no dose adjustment during CRRT. Based on scarce literature data, González de Molina an...
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BACKGROUND Anidulafungin is indicated as a first-line treatment for invasive candidiasis in critically ill patients. In the intensive care unit, sepsis is the main cause of acute renal failure, and treatment with continuous renal replacement therapy (CRRT) has increased in recent years. Antimicrobial pharmacokinetics is affected by CRRT, but few studies have addressed the optimal dosage for ani...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2014
ISSN: 1364-8535
DOI: 10.1186/s13054-014-0618-6